Both are once-weekly injections that quiet appetite and improve blood sugar. Tirzepatide adds a second receptor and produces more weight loss on average; semaglutide is the longest-studied and the more affordable place to start. Here is the honest side-by-side.
| Semaglutide | Tirzepatide | |
|---|---|---|
| Receptors targeted | GLP-1 | GLP-1 + GIP (dual action) |
| Average weight loss | 10–15% of body weight | 15–22% of body weight |
| Injection frequency | Once weekly | Once weekly |
| Appetite effect | Strong reduction in food noise | Strongest reduction in food noise |
| Blood sugar benefit | Improves insulin sensitivity | Improves insulin sensitivity + GIP effect |
| Typical side effects | Nausea, fullness, constipation | Nausea, fullness, constipation |
| Month to month | $185/mo | $249/mo |
| 3-month prepay | $435 total | $597 total |
| Best for | Proven, budget-friendly starting point | Maximum results, higher starting weight |
Above roughly 40 pounds of goal loss, tirzepatide's dual action usually gets you there faster.
Semaglutide starts at $185/month — the most affordable way to begin a medically supervised program.
If semaglutide worked and then plateaued, switching to tirzepatide often restarts progress.
In perimenopause, untreated low estradiol and testosterone blunt results from either medication.
You do not have to decide alone. Complete the 60-second eligibility screening and an independent licensed provider will recommend the medication and dose that fits your history.
Compounded medication, telehealth visits with an independent licensed provider, and our companion app — shipped right to your door.
Maximum results — dual-action GLP-1 / GIP
Based on clinical avg of 15–22% body weight loss
Pay in full · 3 months
$199/mo
$597 billed once · 3-month supply
Month to month
$249/mo
Billed monthly · cancel anytime
What's included
Proven, well-established GLP-1 therapy
Based on clinical avg of 10–15% body weight loss
Pay in full · 3 months
$145/mo
$435 billed once · 3-month supply
Month to month
$185/mo
Billed monthly · cancel anytime
What's included
A $20 doctor fee is collected at checkout when your medication is ready to ship. FedEx overnight cold shipping is included.
Eligibility takes about 60 seconds. Final approval by an independent licensed provider.
Neither medication is appropriate during pregnancy, with a personal or family history of medullary thyroid carcinoma or MEN2, or with a history of pancreatitis. Your screening covers all of it.
A 60-second eligibility screening is all it takes to find out which GLP-1 fits your goals and your history.
