Question 1

What is bioidentical hormone therapy?

Accepted Answer

Bioidentical hormones are identical in molecular structure to the hormones your body naturally produces. Our plans use transdermal creams made from plant-derived ingredients and matched to your own hormonal needs.

Question 2

How are topical creams different from pills or synthetic hormones?

Accepted Answer

Topical hormone creams absorb through the skin directly into the bloodstream, so they enter circulation without first passing through the digestive system and liver, where a lot of breakdown and metabolic change happens with oral medications. That first-pass step is one reason pills can affect things like clotting factors, triglycerides and inflammation markers. Bioidentical hormones are also designed to match the structure of the hormones your body naturally makes, while many synthetic hormones have a slightly altered structure.

Question 3

How quickly will I see results?

Accepted Answer

Timelines vary from person to person. Some women notice changes in energy, mood and sleep within the first couple of weeks, while more complex changes — weight balance, libido, skin health — typically unfold over 6–8 weeks as your body adjusts and levels stabilize. Individual results vary and are not guaranteed.

Question 4

Is it safe?

Accepted Answer

Bioidentical hormones have been studied for both safety and efficacy when used appropriately, and they are designed to match the structure of the hormones your body naturally produces. Delivered as a topical cream, they are absorbed through the skin, which avoids first-pass liver metabolism. Hormone therapy is still not appropriate for everyone — your history, symptoms, labs and risk factors matter, and should be reviewed with a qualified clinician.

Question 5

What is your refund policy?

Accepted Answer

Our refund policy is easy, stress-free, and clearly outlined on our Termination & Refund Policy page.

Question 6

What if I don't see results?

Accepted Answer

Hormone balance is a process. If you are not seeing the results you hoped for, reach out and let us know what is going on so we can help get your plan right. Our goal is not only symptom relief but long-term health, so please be patient with the process and keep communicating with us.

Question 7

Why shouldn't I buy hormones from Amazon or other retailers?

Accepted Answer

While you can find hormone creams online, not all are created equal. Many over-the-counter products use low-quality ingredients, inconsistent dosing, or synthetic alternatives that don't match your body's own hormones. Our creams use USP-grade bioidentical hormones, are prepared in an FDA-registered U.S. facility, and are third-party tested for purity and potency — plus you get ongoing coaching and support.

Question 8

Are these wild yam creams?

Accepted Answer

No. Wild yam root contains a compound called diosgenin, but your body does not have the biochemical ability to convert diosgenin into actual progesterone or other USP-grade bioidentical hormones — that conversion requires a laboratory. Our creams contain real, pharmaceutical-grade bioidentical hormones your body can recognize and use immediately.

Question 9

Why all three creams?

Accepted Answer

The three-cream system addresses the full spectrum of hormone balance. Estrogen, progesterone and testosterone each play unique, complementary roles in how you feel, function and age. Many women are low in all three, and using only one or two can leave gaps in your protocol.

Question 10

What if I have symptoms of androgen excess or too much testosterone?

Accepted Answer

If you have symptoms of androgen excess — acne, increased facial or body hair, irritability — you may want to start with just the estrogen and progesterone creams. The Bi-Est & Progesterone Duo Bundle is designed for that.

Question 11

How is the safety profile of transdermal bio-identical creams different from pills?

Accepted Answer

Transdermal creams are absorbed through the skin directly into the bloodstream, bypassing the liver's first-pass metabolism. That first-pass step is where oral hormones can influence clotting factors, triglycerides, inflammation markers and certain liver-produced proteins. Skipping it tends to produce smoother, more physiologic levels, though no delivery method removes risk entirely — discuss your own risk factors with your clinician.

Question 12

What makes bio-identical different from synthetic?

Accepted Answer

Bio-identical hormones are molecularly identical to the hormones your body naturally makes, so your receptors recognize and metabolize them the way they were designed to. Many synthetic hormones have a slightly altered structure, which can lead to less predictable effects for some women.

Question 13

Are these creams FDA approved?

Accepted Answer

Our creams are compounded in an FDA-registered U.S. facility using USP-grade micronized hormones and are third-party tested for purity and potency. Compounded bio-identical preparations themselves are not FDA-approved as finished drug products — that is true of all custom-compounded hormone therapy.

Question 14

Are there side effects?

Accepted Answer

Most women tolerate transdermal bio-identical creams well, but as with any hormone therapy some may experience temporary breast tenderness, spotting, headaches, mood shifts, or skin sensitivity at the application site as the body adjusts. Dosing is personalized and easy to titrate.

Question 15

Who should not use these creams?

Accepted Answer

Hormone therapy is not appropriate for everyone. Women who are pregnant or breastfeeding, or who have a history of hormone-sensitive cancers, active blood clots, unexplained vaginal bleeding, or certain liver or cardiovascular conditions, should not begin therapy without a thorough evaluation by their physician.

If you need to do something about it —
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Not sure which creams you need?

Three creams. One complete system.

Bi-Est Estrogen Cream (Estriol + Estradiol)

Progesterone 75 mg Topical Cream

DHEA 50 mg Topical Cream

Prescription-strength BHRT — without the prescription hassle.

Bio-identical & third-party tested ingredients

92% of women reported improvement

Ingredients

Your ovaries never made just one hormone.

Hear from 5,000+ women

Every cream is doctor formulated.

Learn more about hormones

Bioidentical Hormones: A Complete Guide

Find Your Hormone

Find Your Symptoms

Doctor-Guided Hormone Therapy

Common questions

Find the creams that fit your body

If you need to do something about it — we have the answer.