BioIdentical Hormone Combo Cream - Biest/Progesterone/DHEA
The bio-identical cream your body recognizes.
Perimenopause and menopause don’t take one hormone away — they take several. Our thoughtfully formulated combo cream restores the three that matter most: Bi-Est (estriol + estradiol), Progesterone, and DHEA — in a single, once-daily topical application your body actually knows how to use.
No synthetic hormones. No horse-derived estrogens. Just the exact molecules you’ve been making since puberty, in a formula delivered through the skin for steady, day-long balance.
Three hormones, engineered to work in balance.
Estrogen alone can tip you into estrogen dominance. Progesterone alone can’t address hot flashes. DHEA alone won’t restore vaginal comfort. Combined thoughtfully — they do what no single hormone ever could on its own.
Curious how this fits into a full routine? Explore our bioidentical hormone therapy approach.
The estrogen your body understands
Bi-Est (Estriol + Estradiol)
A physiologic 80/20 blend of estriol and estradiol — the same bio-identical ratio compounding pharmacies use — to support hot flashes, night sweats, mood, sleep, vaginal comfort, and skin quality.
The calming counterbalance
Progesterone
Bio-identical progesterone is estrogen's natural partner — helping quiet anxiety, deepen sleep, ease PMS, and protect the uterine lining in women who still have a uterus.
The vitality precursor
DHEA
A foundational adrenal hormone that supports libido, energy, lean muscle, cognition, and healthy aging — declining sharply from your 30s onward.
Feel like yourself again.
A short list of what women consistently notice within the first few weeks — and what builds beautifully over months of consistent use.
Ease Hot Flashes & Night Sweats
Bi-Est directly supports the estrogen receptors that regulate temperature, so vasomotor symptoms quiet down — often within the first few weeks of consistent use.
Sleep Deeper, Wake Rested
Progesterone binds to GABA receptors — the same calming pathway sleep medications target — helping you fall asleep faster and stay asleep through the night.
Stabilize Mood & Anxiety
Bio-identical progesterone and estrogen work together to steady the neurochemistry behind irritability, low mood, and that wired-but-tired perimenopause spiral.
Restore Energy & Libido
DHEA rebuilds the hormonal foundation your 30s and 40s quietly erode — supporting stamina, motivation, and a healthy sex drive.
Skin, Hair & Vaginal Comfort
Estrogen and DHEA together help restore skin thickness, collagen, and vaginal tissue hydration — the tissues that thin fastest as hormones decline.
Long-Term Bone & Brain Support
Consistent bio-identical estrogen replacement protects bone density and supports cognitive resilience through perimenopause and beyond.
If you’re nodding at three or more, it’s time.
These are the symptoms our combo cream is designed to address — not by masking, but by restoring the underlying hormones behind them.
Bypasses the liver
Skips first-pass metabolism, which is associated with a more favorable safety profile than oral estrogens.
Steady day-long levels
No peaks and valleys. Your hormones stay in the physiologic range hour to hour.
Consistent Suggested-Use Amount
One suggested-use amount, applied consistently — not a one-size-fits-all pill.
Easy daily ritual
One application. Thirty seconds. Rotate sites. Wash your hands. Done.
Delivered through the skin, the way your body prefers.
Oral hormones must pass through the liver before ever reaching your tissues — a detour that alters metabolism and drives many of the safety concerns older HRT is known for. Applying bio-identical hormones through the skin puts them directly into circulation, at steady physiologic levels, all day long.
It’s the same delivery method used across our full BHRT program — because it works, and because it’s gentle enough to stay on long-term.
Balance in three simple steps.
Step 01
Cleanse & Prep
Start with clean, dry skin — inner forearms, inner thighs, or behind the knees work best.
Step 02
Apply Your Suggested Amount
Rub in the suggested-use amount once daily. Rotate sites each day to keep absorption consistent.
Step 03
Let It Work
Wash your hands, get dressed, and go. Steady, physiologic levels build over the following weeks.
What’s not in the bottle matters, too.
Manufactured to consistent, quality specifications — never the shortcuts of legacy hormone therapy.
Questions? We’ve got answers.
Everything you need to know about the Bi-Est / Progesterone / DHEA combo cream, its suggested-use directions, and what to expect from your first bottle.
Let's find out if hormone therapy is right for you
Take the short assessment and see whether you're a fit for bioidentical hormone care.